Transdermal flux enhancing compositions

Details Transdermal flux enhancing compositions Transdermal flux enhancing compositions

A - Human Necessities

61

K

167/159

A61K 47/00 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/22 (2006.01)

Patent

CA 1331137

TRANSDERMAL FLUX ENHANCING COMPOSITIONS Abstract A transdermal flux enhancing pharmaceutical composition for transdermal administration to a human or lower animal subject comprising a safe and effective amount of a pharmacologically active compound or a prodrug thereof, an aqueous solvent system comprising from about 15 to 75% by volume of one or more water miscible solvents, and a penetration enhancer selected from certain 1-alkylazacycloheptan-2-ones and cls-olefin compounds of the formula CH3(CH2)xCH=CH(CH2)yR3 where R3 is CH2OH, CH2NH2 or COR4 and R4 is OH or (C1-C4)alkoxy, x and y are each an integer from 3 to 13 and the sum of x and y is from 10 to 16; methods for their use in treating various illnesses in a human or lower animal by transdermal administration of said composition.

592011

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