A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/70 (2006.01) A61K 31/473 (2006.01) A61K 31/485 (2006.01) A61P 15/10 (2006.01) A61P 25/00 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01)
Patent
CA 2337516
Pharmaceutical composition comprising R(-)-propylnorapomorphine hydrochloride or S(+)-propylnorapomorphine hydrochloride and/or derivatives thereof, together with antioxidants, solubilizers and permeation activators to facilitate the passage of the active principle through the skin. The pharmaceutical composition is used in matrix (3, 3', 3") of a transdermal patch (1, 1', 1"), for the treatment of disorders of the Central Nervous System and in particular for the treatment of sexual impotence, hemicrania, Parkinson's disease and psychotic disorders. The release of the active principle can be modified by varying the concentrations of the solubilizers or of the permeation activators, or by providing a permeable membrane (4).
Cette composition pharmaceutique renferme du chlorhydrate de R(-)-propylnorapomorphine ou du chlorhydrate de S(+)-propylnorapomorphine et/ou leurs dérivés ainsi que des antioxydants, des agents de solubilisation et des activateurs de perméation destinés à faciliter le passage du principe actif à travers la peau. On utilise cette composition pharmaceutique, placée dans la matrice (3, 3', 3'') d'un timbre transdermique (1, 1', 1''), pour traiter des troubles du système nerveux central et, notamment, pour traiter l'ataraxie génitale, l'hémicrânie, la maladie de Parkinson ainsi que des troubles psychotiques. Il est possible de modifier la libération du principe actif en changeant la concentration des agents de solubilisation ou des activateurs de perméation ou bien en utilisant une membrane perméable (4).
Kirby Eades Gale Baker
Unihart Corporation
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