Transdermal therapeutic system comprising as active...

Details Transdermal therapeutic system comprising as active... Transdermal therapeutic system comprising as active...

A - Human Necessities

61

K

167/231

A61K 31/485 (2006.01) A61K 9/70 (2006.01)

Patent

CA 2030178

The controlled release of buprenorphine or the pharma- ceutically acceptable salts thereof to the skin over a period of time of at least 24 hours is ensured by a transdermal therapeutic system consisting of a backing layer which is impermeable to the active substance, a pressure-sensitive adhesive reservoir layer, and op- tionally a removable protective layer. Said reservoir layer of said system comprises 20 to 90%-wt polymeric material, 0.1 to 30%-wt softener, 0.1 to 20%-wt bupre- norphine base or one of the pharmaceutically accepta- ble salts thereof, and 0.1 to 30%-wt solvent for the active substance base.

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