A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/70 (2006.01) A61K 9/00 (2006.01) A61K 31/46 (2006.01)
Patent
CA 2643037
Described are flexible, finite systems for the transdermal administration of scopolamine, comprising: (a) a polymer matrix comprising a polymer blend comprising (i) a non-functional acrylic-based polymer constituting at least about 60% by weight of the dry weight of the polymer matrix, and (ii) an amine-resistant capped silicone polymer constituting not more than about 30% by weight of the dry weight of the polymer matrix; and (b) scopolamine solubilized in the polymer matrix, wherein the flexible, finite system is substantially free of vinyl acetate and polar components. In some embodiments, the polymer matrix also comprises a non-polar penetration enhancer. Methods of making and using such flexible, finite systems also are described.
L'invention concerne des systèmes finis et flexibles destinés à l'administration transdermique de scopolamine, comprenant : (a) une matrice polymère comprenant un mélange polymère comprenant (i) un polymère à base d'acrylique non fonctionnel constituant au moins environ 60 % en poids du poids sec de la matrice polymère, et (ii) un polymère de silicone coiffé résistant aux amines constituant au plus environ 30 % en poids du poids sec de la matrice polymère; et (b) de la scopolamine solubilisée dans la matrice polymère, le système fini et flexible étant sensiblement exempt d'acétate de vinyle et de composants polaires. Selon certains modes de réalisation, la matrice polymère comprend également un amplificateur de pénétration non polaire. L'invention concerne également des procédés de fabrication et d'utilisation de tels systèmes finis et flexibles.
Kanios David P.
Mantelle Juan A.
Noven Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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