Transdermal therapeutic system containing pergolide

Details Transdermal therapeutic system containing pergolide Transdermal therapeutic system containing pergolide

A - Human Necessities

61

K

A61K 31/48 (2006.01) A61K 9/70 (2006.01)

Patent

CA 2327187

The invention relates to a transdermal therapeutic system for the transcutaneous administration of pergolide over several days and to a method for producing such a system without the use of solvents. The transdermal therapeutic system contains a pergolide-containing matrix mass in layer form which contains a (meth)acrylate copolymer containing ammonio groups or a mixture of a (meth)acrylate copolymer containing amino groups and a (meth)acrylate polymer containing carboxyl groups, between 10 and 50 weight % propylene glycol and up to 5 weight % pergolide.

L'invention concerne un système thérapeutique transdermique servant à l'administration transcutanée de pergolide pendant plusieurs jours, ainsi qu'un procédé de production d'un tel système sans utilisation de solvants. Le système thérapeutique transdermique présenté comporte une masse matricielle contenant du pergolide, se présentant sous la forme d'une couche, qui contient un copolymère de (méth)acrylate contenant des groupes amonio ou bien un mélange d'un copolymère de (méth)acrylate contenant des groupes amino et d'un polymère de (méth)acrylate contenant des groupes carboxyle, 10 à 50 % de propylène glycol et jusqu'à 5 % en poids de pergolide.

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