Transdermal therapeutic system for administration of...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/70 (2006.01) A61K 31/4468 (2006.01)

Patent

CA 2721013

What is disclosed is a transdermal therapeutic system for administration of an active ingredient through the skin, comprising: (a) a back layer, (b) a reservoir present on the back layer, comprising the active ingredient, polyisobutylene, a gel former and a plasticizer, a portion of the active ingredient in the reservoir being present in the form of undissolved particles and the content of gel formers in the reservoir being at most 4% by weight (based in the total weight of the reservoir), the active ingredient being Fentanyl or an analogue thereof.

L'invention porte sur un système thérapeutique transdermique destiné à l'administration d'un principe actif à travers la peau, comprenant : (a) une couche postérieure, (b) un réservoir se trouvant sur la couche postérieure, contenant le principe actif, du polyisobutylène, un gélifiant et un plastifiant, une partie du principe actif dans le réservoir se présentant sous la forme de particules non dissoutes et la teneur en gélifiant dans le réservoir étant au plus de 4 % en poids (par rapport au poids total du réservoir), le principe actif étant le fentanyl ou une substance analogue.

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