Transdermal therapeutic system identified without printing...

A - Human Necessities – 61 – K

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A61K 9/70 (2006.01) A61L 15/16 (2006.01) A61L 15/44 (2006.01)

Patent

CA 2220341

A transdermal therapeutic system is disclosed to administer active substances through the skin to the human body. The backing layer consists of pharmaceutically usual plastic foil laminates made of thermoplastic materials that melt at a low temperature on its outer side and of thermoplastic materials that melt at a higher temperature facing the skin. The backing layer needs to be identified, for example by printing. Using pigments or lacquers for printing creates problems, however, because of their toxicological and technological inconvenients, as well as legal restrictions that apply to medicaments. According to the invention, therefore, the identification code does not consist of a dye or pigment layer, but of a modification of the surface structure of the backing layer that corresponds to the identification code.

L'invention concerne un système thérapeutique transdermique d'administration de principes actifs au corps humain à travers la peau. La couche de support de ce système est constituée de films plastiques stratifiés usuels en pharmacie, comportant une couche extérieure en matières thermoplastiques qui fondent à basse température et une couche face à la peau constituée de matières thermoplastiques qui fondent à une température plus élevée. La couche de support doit être pourvue d'une identification, par exemple appliquée par impression. L'impression avec des pigments ou des vernis pose toutefois des problèmes, étant donné que ces pigments ou ces vernis présentent des inconvénients à cause de leur toxicité, de la technologie à utiliser pour les appliquer et des prescriptions légales en matière de médicaments. Leur code d'identification est donc appliqué non pas sous forme d'une couche d'encre ou de pigment, mais sous forme d'une modification de la structure de la surface de la couche de support.

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