Transdermal therapeutic system which contains a d2 agonist...

Details Transdermal therapeutic system which contains a d2 agonist... Transdermal therapeutic system which contains a d2 agonist...

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61K 31/381 (2006.01)

Patent

CA 2326630

The invention relates to a transdermal therapeutic system comprising a back layer which is inert with respect to the constituents of the matrix, a self-adhesive matrix layer containing an effective quantity of (-)-5,6,7,8,-tetrahy- dro-6-[propyl[2-(2-thienyl)-ethyl]amino]-1-naphthol, and a protective film which is to be removed before use. The invention is characterized by a matrix based on a non-aqueous polymer adhesive system, said system being based on acrylate or silicon, with a solubility for (-)-5,6,7,8,-tetrahy- dro-6-[propyl[2-(2-thienyl)-ethyl]amino]-1-naphthol of >=5 % g/g. Said matrix is essentially free of inorganic silicate particles.

L'invention concerne un système thérapeutique transdermique comportant une couche postérieure inerte vis-à-vis des constituants de la matrice, une couche matricielle autocollante présentant du (-)-5,6,7,8-tétrahydro-6-[propyl[2-(-2-thiényl)-éthyl]amino]-1-naphtol dans des quantités efficaces, et une feuille protectrice à retirer avant utilisation. L'invention est caractérisée par une matrice à base d'un système d'adhésif polymère non aqueux, à base d'acrylate ou de silicone, présentant une solubilité vis-à-vis du (-)-5,6,7,8-tétrahydro-6-[propyl[2-(-2-thiényl)-éthyl]amino]-1-naphtol >/=5 % g/g, cette matrice étant pratiquement exempte de particule de silicate inorganique.

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