Transdermal therapeutic system with small application-area...

Details Transdermal therapeutic system with small application-area... Transdermal therapeutic system with small application-area...

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61M 37/00 (2006.01) B32B 3/10 (2006.01) B32B 7/02 (2006.01)

Patent

CA 2250025

A transdermal therapeutic system for the release of active substances to a substrate is characterized by the structure of the system comprising a substrate (1) provided with a separating layer (2), a film layer (3) comprising the active substance, and a protective layer (4) provided with a nonstick finish, the separating layer (2) consisting of a material whose bond to the film layer (3) may be abolished. By means of printing methods, such systems having small application thickness and high flexibility can be manufactured, it being possible to provide a substrate that has been rendered abhesive as an alternative to the substrate/separating layer-complex. A printing method limiting the active substance-containing region to the application site reduces disposal problems.

Système thérapeutique transdermique destiné à délivrer des matières actives à un substrat, caractérisé en ce qu'il présente une composition comprenant une couche support (1) présentant une couche de séparation (2), une couche formée d'un film (3) contenant la matière active et une couche de protection (4) munie d'un adhésif, système dans lequel la couche de séparation (2) est constituée par un matériau dont la liaison avec le film (3) peut être annulée. De tels systèmes à faible épaisseur et grande souplesse peuvent être obtenus suivant un processus d'impression, dans lequel on peut prévoir, dans une variante, pour le complexe couche support/couche de séparation, un substrat muni d'un adhésif. Un processus d'impression limitant le domaine contenant la matière active à la surface d'application permet de réduire les problèmes d'élimination.

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