Transdermal treatment with mast cell degranulating agents...

Details Transdermal treatment with mast cell degranulating agents... Transdermal treatment with mast cell degranulating agents...

A - Human Necessities

61

K

A61K 47/00 (2006.01) A61K 9/06 (2006.01) A61K 9/70 (2006.01) A61K 31/415 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2114968

TRANSDERMAL TREATMENT WITH MAST CELL DEGRANULATING AGENTS FOR DRUG-INDUCED HYPERSENSITIVITY ABSTRACT Methods and compositions for inhibiting or preventing the skin irritating or sensitizing effects of a skin irritating or sensitizing component of a dermal or transdermal drug delivery system are disclosed. The composition comprises a mast cell degranulating agent which is capable of inducing a state of immunological tolerance to the skin sensitizing agent by delivery prior to, or at the onset of transdermal drug delivery. Such an agent, preferably cis-urocanic acid or an analogue or metabolite thereof, can be administered before, during or after each transdermal drug delivery to achieve immune tolerance countersensitization. Alternatively, the agent can be used to induce countersensitization. The agent is preferably capable of permeating the epidermis and is administered transdermally. Novel methods and compositions comprising cis-urocanic acid or an analogue or metabolite thereof to obtain anti- inflammatory effects are also disclosed.

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