Transdermal verapamil delivery device

Details Transdermal verapamil delivery device Transdermal verapamil delivery device

A - Human Necessities

61

K

167/159, 167/251

A61K 9/00 (2006.01) A61K 9/70 (2006.01) A61K 31/275 (2006.01)

Patent

CA 1276111

ABSTRACT OF THE DISCLOSURE A transdermal drug delivery device for administering 5-[(3,4-dimethoxyphenethyl) methylamino]- 2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile com- prising a permeable matrix of silicone elastomer or other bioacceptable lipophilic polymer material having an effective cardiovascular affecting amount of active drug and an effective drug release promoting amount of a transport enhancing agent dispersed therein. The back of the matrix is covered with an occlusive backing and the face of the matrix is covered with a biocompatible adhesive such as a silicone adhesive also having a transport enhancing agent dispersed therein. A supply of skin permeation enhancing agent may be provided adjacent the adhesive layer such that the skin of a patient to whom the device is applied is pretreated with permeation enhancing agent. Particularly preferred skin permeation and transport enhancing agents include N,N-diethyl-m-toluamide, isopropyl myristate and similar compounds.

512950

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