Transdermally administered dextromethorphan as antitussive...

A - Human Necessities – 61 – K

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Details

A61K 31/485 (2006.01) A61K 9/70 (2006.01) A61K 47/40 (2006.01)

Patent

CA 2251966

Device for transdermal administration of dextromethorphan, (+)-3-methoxy-17- methyl-9a,13a,14a-morphinan, optionally encompass-ing salts, prodrugs and metabolites thereof, optionally together with pharmaceutically acceptable carrier(s) to a human being or an animal in order to achieve an antitussive effect. Use of an antitussive compound comprising dextromethorphan, (+)-3-methoxy-17-methyl-9a, 13a, 14a--morphinan, optionally encompassing salts, prodrugs and metabolites thereof, and optionally together with pharmaceutically acceptable car-rier(s), for the manufacture of a composition to be administered transdermally for achieving an antitussive effect. Method for achieving an antitussive effect in a living body by transdermal administration of a compound comprising dextromethorphan, (+)-3-methoxy-l7-methyl--9a,13a,14a- morphinan, optionally encompassing salts, prodrugs and metabolites thereof, and optionally together with pharmaceutically acceptable carrier(s).

L'invention porte: sur un dispositif d'administration transdermique à l'homme ou à l'animal de dextrométhorphane, (+)-3-méthoxy-17-méthyl-9a,13a,14a-morphinane, englobant facultativement ses sels, ses promédicaments, et ses métabolites, éventuellement associés à un ou plusieurs excipients pharmacocompatibles, afin d'obtenir un effet antitussif; sur l'utilisation d'un composé antitussif de dextrométhorphane, (+)-3-méthoxy-17-méthyl-9a,13a,14a-morphinane, englobant facultativement ses sels, ses promédicaments, et ses métabolites, éventuellement associés à un ou plusieurs excipients pharmacocompatibles, en vue de la fabrication d'une préparation à administrer par voie transdermique produisant un effet antitussif; et sur un procédé d'obtention d'un effet antitussif dans un corps vivant par administration transdermique d'un composé antitussif de dextrométhorphane, (+)-3-méthoxy-17-méthyl-9a,13a,14a-morphinane, englobant facultativement ses sels, ses promédicaments, et ses métabolites, éventuellement associés à un ou plusieurs excipients pharmacocompatibles.

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