Transducible delivery of nucleic acids by reversible...

Details Transducible delivery of nucleic acids by reversible... Transducible delivery of nucleic acids by reversible...

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 31/7088 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2659103

This disclosure relates to nucleic acid constructs modified to have a reduced net anionic charge. In some aspects the constructs comprise phosphodiester and/or phosphothioate protecting groups. The disclosure also provide methods of making and using such constructs.

La présente invention concerne des constructions d'acide nucléique modifiées de manière à avoir une charge anionique nette réduite. Selon certains aspects, les constructions comprennent des groupes de protection phosphodiester et/ou phosphotioate. L'invention propose aussi des procédés de fabrication et d'utilisation de constructions de ce type.

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