C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 31/713 (2006.01) A61K 38/16 (2006.01) C12N 15/10 (2006.01) C12N 15/62 (2006.01) C12N 15/87 (2006.01) C12P 21/02 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2638915
The disclosure provides fusion polypeptides and constructs useful in delivering anionically charged nucleic acid molecules including diagnostics and therapeutics to a cell or subject. The fusion constructs include a protein transduction domain and a nucleic acid binding domain, or a protein transduction domain and a nucleic acid that is coated with one or more nucleic acid binding domains sufficient to neutralize an anionic charge on the nucleic acid. Also provided are methods of treating disease and disorders such as cell proliferative disorders.
La présente invention concerne des polypeptides de fusion et des constructions utiles lors de la livraison de molécules d'acide nucléique à charge anionique, ainsi que le diagnostic et le traitement d'une cellule ou d'un sujet. Les constructions de fusion comprennent un domaine de transduction de protéine et un domaine de liaison à l'acide nucléique, ou un domaine de transduction de protéine et un acide nucléique revêtu d'un ou de plusieurs domaines de liaison à l'acide nucléique et ce, en quantité suffisante pour pouvoir neutraliser une charge anionique sur l'acide nucléique. L'invention a également trait aux procédés destinés au traitement de maladies et de troubles tels des troubles de la prolifération cellulaire.
Dowdy Steven F.
Eguchi Akiko
Meade Bryan
Wadia Jehangir S.
Mbm Intellectual Property Law Llp
The Regents Of The University Of California
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