Transducible dna-binding proteins

Details Transducible dna-binding proteins Transducible dna-binding proteins

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01)

Patent

CA 2528830

Disclosed is a chimeric protein comprising: a) a plurality of zinc finger domains; and b) a heterologous protein transduction domain, effective for translocating the protein across a cellular membrane. The chimeric protein can be efficiently transduced into cultured eukaryotic cells in which they regulate specific target genes. Thus, artificial transcription factors that include a PTD can be used to produce protein drugs that regulate endogenous genes and protein drugs that alter cell behavior in vitro and in vivo.

L'invention concerne une protéine chimère comprenant : a) plusieurs domaines à doigt de zinc ; et b) un domaine de transduction de protéine hétérologue, efficace en matière de translocation de la protéine à travers une membrane cellulaire. On peut transduire efficacement la protéine chimère dans des cellules eucaryotes cultivées dans lesquelles des gènes cibles spécifiques sont régulés. Les facteurs de transcription artificiels qui comportent un domaine de transduction de protéine (PTD) peuvent être utilisés pour produire des médicaments protéiques qui régulent les gènes endogènes et des médicaments protéiques qui modifient le comportement cellulaire in vitro et in vivo.

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