C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2461065
The invention provides an isolated or purified nucleic acid molecules consisting essentially of the nucleotide sequence encoding either transductin- 1 (TDC1) or transductin-2 (TDC2), related and derivative nucleic acid molecules, vectors comprising the isolated or purified nucleic acid sequences, cells comprising such vectors, polypeptides encoded by the nucleic acid molecules, monoclonal antibodies and cell lines producing the monoclonal antibodies. The invention also provides methods of treating, prognosticating and monitoring hearing loss.
L'invention porte: sur des molécules d'acide nucléique isolées et purifiées consistant essentiellement en séquences nucléotidiques codant soit pour la transductine-1 (TDC1) ou la transductine-2 (TDC2), sur des molécules d'acide nucléique parentes et dérivées, sur des vecteurs comportant lesdites séquences d'acide nucléique isolées et purifiées, sur des cellules comprenant lesdits vecteurs, sur des polypeptides codés par les molécules d'acide nucléique, sur des anticorps monoclonaux, et sur les lignées de cellules produisant lesdits anticorps monoclonaux. L'invention porte également sur des méthodes de traitement, pronostic et suivi des déficits auditifs.
Friedman Thomas
Griffith Andrew J.
Kurima Kiyoto
Wilcox Edward
Ridout & Maybee Llp
The Government Of The United States Of America
LandOfFree
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