Transduction of recombinases for inducible gene targeting

Details Transduction of recombinases for inducible gene targeting Transduction of recombinases for inducible gene targeting

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A01K 67/027 (2006.01) A61K 38/43 (2006.01) A61K 47/48 (2006.01) C07K 14/035 (2006.01) C07K 14/16 (2006.01) C07K 14/435 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2396149

The present invention provides the use of a fusion protein comprising a site- specific DNA recombinase domain and a protein transduction domain for preparing an agent for inducing target gene alteration in a living organism or in cultured cells, suitable fusion proteins and a method for theproduction of said fusion proteins.

L'invention concerne l'utilisation d'une protéine de fusion comprenant un domaine d'ADN recombinase spécifique de site et un domaine de transduction de protéines pour la préparation d'un agent afin d'induire une modification du gène cible dans un organisme vivant ou dans des cellules cultivées. L'invention concerne également des protéines de fusion appropriées et une méthode de production desdites protéines de fusion.

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