C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
150/13, 195/1.10
C12N 5/06 (2006.01) A61K 39/395 (2006.01) C07K 14/095 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/12 (2006.01) C12P 21/08 (2006.01) G01N 33/532 (2006.01) G01N 33/566 (2006.01)
Patent
CA 1341055
Non-human mammalian. cell lines which express the major human rhinovirus receptor protein. The cell lines are prepared by gene transfection of human DNA, such as HeLa cell DNA, into non-human mammalian cells, such as mouse cells. Primary transfectants can be transfected into further non-human mammalian cells to provide secondary transfectants. Cloning of secondary transfectants yields cell lines that exhibit enhanced expression of the surface receptor protein. The transfectant cell lines provide a means for cloning the major human rhinovirus receptor protein gene and immunogens for producing antibodies, particularly monoclonal antibodies, against the receptor protein. A general method for screening drug candidates for their ability to block ligand binding to a human cell surface receptor protein is also provided.
584200
Davis Gary
Greve Jeffrey M.
Mcclelland Alan
Meyer Ann Marie
Borden Ladner Gervais Llp
Davis Gary
Greve Jeffrey M.
Mcclelland Alan
Meyer Ann Marie
LandOfFree
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