Transfection competent molecules

Details Transfection competent molecules Transfection competent molecules

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 9/127 (2006.01) A61K 47/48 (2006.01) C07K 14/00 (2006.01)

Patent

CA 2195169

The invention relates to conjugates of lipids and basic, membrane disturbing peptides. particularly compounds of the formulae (R-CONH)n-R3 (I) and (R-S-S)n-R3 (II) wherein R is the hydrocarbyl moiety of a straight-chain or branched-chain, saturated or unsaturated aliphatic carboxylic acid, or a phospholipid moiety having a free valence bond; R3 is a basic membrane disturbing peptide having a free valence bond at one or two carbon atom(s); and n is 1 or 2. which can be used as a vector for transfecting a cell with a polynucleotide or any other anionic macromolecule.

ette invention a trait à des conjugués de lipides et de peptides perturbant la membrane de base et plus particulièrement de composés de formule (R-CONH)n-R3 (I) et (R-S-S)n-R3 (II), où R est le groupe hydrocarbyle d'un chaîne droite ou ramifiée, saturée ou non, d'acide carboxylique aliphatique, ou un groupe phospholipidique à une liaison libre, où R3 est un peptide perturbateur de la membrane de base possédant une liaison libre à un ou deux atomes de carbone et où n est 1 ou 2, et qui peut servir de vecteur pour la transfection d'un polynucléotide ou d'une autre macromolécule anionique dans une cellule.

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