Transfection in magnetically driven continuous flow

Details Transfection in magnetically driven continuous flow Transfection in magnetically driven continuous flow

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 48/00 (2006.01) C12M 1/42 (2006.01)

Patent

CA 2677171

Biological cells and other membranous structures are transfected in a flow-through system by first rendering the structures magnetically active such that they respond to a magnetic field, suspending the structures in a solution of an exogenous species with which the structures are to be transfected, then placing the suspension in a channel and using a moving magnetization pattern along the channel wall to cause the structures to travel through the channel. Along their path of travel, the structures pass a transmitter that emits transfection energy sufficient to cause the exogenous species in the suspension to permeate the structure membranes and enter the interiors of the structures.

L'invention concerne la transfection de cellules biologiques et d'autres structures membranaires dans un système à écoulement, ladite transfection étant réalisée par les étapes consistant à : rendre tout d'abord les structures magnétiquement actives de manière à ce qu'elles répondent à un champ magnétique, mettre les structures en suspension dans une solution d'une espèce exogène avec laquelle les structures doivent être transfectées, puis placer la suspension dans un canal et utiliser le motif d'aimantation mobile le long de la paroi du canal pour faire se déplacer les structures dans le canal. Le long de leur déplacement, les structures passent dans un émetteur qui émet une énergie de transfection suffisante pour que les espèces exogènes de la suspension traversent les membranes des structures et entrent dans l'intérieur des structures.

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