Transfection of lung via aerosolized transgene delivery

Details Transfection of lung via aerosolized transgene delivery Transfection of lung via aerosolized transgene delivery

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 9/133 (2006.01) A61K 31/70 (2006.01) A61K 47/24 (2006.01) A61K 47/28 (2006.01) A61K 47/48 (2006.01) C07K 14/47 (2006.01) C12N 15/88 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2126103

Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclosed. Lipid carrier-nucleic acid complexes are prepared then delivered via aerosol to the lung airway. The inven- tion provides a direct method for transforming pulmonary cells as a means for treating disorders of the lung as for providing a means for delivering substances systematically following expression in the lung.

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