C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/87 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2391881
The invention relates to the use of a carboxy-terminal fragment of the Ki-67 protein or of an active part, fragment or homologue thereof as a compound that can be used for intracellular transfer and for the introduction in and the release by the cells. The invention further relates to transfer compounds that contain the above-mentioned Ki-67 protein and to the vectors encoding the same. The invention also relates to corresponding pharmaceutical compositions and to the use of the transfer protein as an excipient or active agent in the treatment of diseases.
L'invention concerne l'utilisation d'un fragment carboxy-terminal de la protéine Ki-67 ou d'une partie active, d'un fragment actif ou d'un homologue de ce dernier, en tant que composé approprié pour le transfert intracellulaire et l'absorption ou la sécrétion cellulaire. L'invention concerne en outre des composés de transfert qui contiennent l'extrémité carboxy-terminale, mentionnée ci-dessus, de la protéine Ki-67, ainsi que des vecteurs la codant. L'invention concerne en outre des compositions pharmaceutiques et l'utilisation de la protéine de transfert comme excipient ou principe actif dans le traitement de maladies.
Gerdes Johannes
Scholzen Thomas
Wohlenberg Claudia
Faustus Forschungs Cie. Translational Cancer Research Gmbh
Robic
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