Transfer hydrogenation process

Details Transfer hydrogenation process Transfer hydrogenation process

C - Chemistry, Metallurgy

07

B

C07B 43/04 (2006.01) C07B 53/00 (2006.01) C07D 209/08 (2006.01) C07D 217/10 (2006.01)

Patent

CA 2343088

A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal neutral hydrocarbyl complex which is coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centres. The hydrogen donor is advantageously a mixture of triethylamine and formic acid. The process can be employed to transfer hydrogenate iminium salts, which are preferably prochiral.

Cette invention concerne une procédé d'hydrogénation par transfert catalytique. Le catalyseur utilisé ici est un complexe métallifère hydrocarbyle neutre coordonné à des ligands bidentés. Les métaux sont de préférence du rhodium, du ruthénium et de l'iridium. Comme ligands, on préférera des diamines et des amino-alcools, en particulier ceux qui comprennent des atomes chiraux. Comme donneur d'hydrogène, il est avantageux d'utiliser un mélange de triéthylamine et d'acide formique. Ce procédé convient pour le transfert de sels d'iminium hydrogéné, de préférence prochiraux.

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