Transfer of molecules into the cytosol of cells

Details Transfer of molecules into the cytosol of cells Transfer of molecules into the cytosol of cells

C - Chemistry, Metallurgy

12

N

C12N 13/00 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2199290

A method for releasing molecules into the cytosol of cells without killing the majority of the cells by allowing the molecules to be taken up in endosomes, lysosomes or other cell compartments and use light activation of photosensitizing compounds to rupture the membranes of the endosomes, lysosomes or other cell compartments, is described.

La présente invention concerne un procédé permettant de libérer des molécules dans le cytosol des cellules sans tuer la majorité des cellules. Le procédé consiste à permettre aux molécules d'être reçues dans les endosomes, lysosomes ou autres constituants cellulaires, et à activer par la lumière des composés photosensibilisants pour provoquer la rupture des membranes des endosomes, lysosomes ou autres constituants cellulaires.

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