Transferrin binding proteins of pasteurella haemolytica and...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/31 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/102 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C07K 14/285 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2239226

Transferrin binding proteins from Pasteurella haemolytica and nucleic acid molecules encoding the proteins are disclosed. Antibodies against the proteins are disclosed. The invention also relates to vaccines containing the proteins of the invention. The invention also provides methods for identifying substances which affect the binding of transferrin to the proteins and methods for screening for agonists or antagonists of the binding of the proteins and transferrin.

Cette invention concerne des protéines provenant de Pasteurella haemolytica et se liant à la transférine, ainsi que des molécules d'acide nucléique codant ces protéines. Cette invention concerne également des anticorps dirigés contre ces protéines, ainsi que des vaccins contenant les protéines décrites dans la présente invention. Cette invention concerne enfin des procédés d'identification de substances altérant la liaison de la transférine aux protéines, ainsi que des procédés de criblage d'agonistes ou d'antagonistes de la liaison entre les protéines et la transférine.

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