Transferrin receptor genes of moraxella

Details Transferrin receptor genes of moraxella Transferrin receptor genes of moraxella

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 31/70 (2006.01) A61K 39/02 (2006.01) A61K 48/00 (2006.01) C07K 14/195 (2006.01) C07K 14/21 (2006.01) C12Q 1/68 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2248095

Purified and isolated nucleic acid molecules are provided which encode transferrin receptor proteins of Moraxella, such as M. catarrhalis or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce recombinant transferrin receptor proteins Tbp1 and Tbp2 of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection.

La présente invention concerne des molécules d'acide nucléique purifiées et isolées codant pour les protéines réceptrices de la sidérophiline issues du genre Moraxella, tels que M. catarrhalis, ou pour un fragment ou analogue de la protéine réceptrice de la sidérophiline. La séquence d'acide nucléique convient à la production de protéines recombinantes réceptrices de la sidérophiline, en l'occurrence les protéines Tpb1 et Tpb2 de la souche du genre Moraxella exempte d'autres protéines de la souche Moraxella, et ce à des fins de diagnostic et de traitement médical. En outre, la molécule d'acide nucléique convient au diagnostic d'infection.

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