Transferrin receptor specific antibody-neuropharmaceutical...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C07K 14/79 (2006.01) C12N 9/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2066244

2066244 9103259 PCTABS00003 The present invention pertains to a method for delivering a neuropharmaceutical agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of an antibody-neuropharmaceutical agent conjugate wherein the antibody is reactive with a transferrin receptor. Other aspects of this invention include a delivery system comprising an antibody reactive with a transferrin receptor linked to a neuropharmaceutical agent and methods for treating hosts afflicted with a disease associated with a neurological disorder.

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