C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/495 (2006.01) C07K 16/22 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2215350
The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
L'invention se rapporte à des polypeptides donnant lieu de facteur de croissance transformant alpha HII et aux polynucléotides qui effectuent le codage de tels polypeptides. On décrit également une procédure qui permet d'obtenir les polypeptides en question par génie génétique et certaines utilisations des polypeptides à des fins thérapeutiques parmi lesquelles figurent: l'accélération de la guérison des blessures, le traitement des troubles neurologiques, oculaires, rénaux et hépatiques, et la stimulation de l'embryogenèse et l'angiogenèse. L'invention concerne également des antagonistes de ces polypeptides et leur utilisation dans le traitement de la néoplasie. Enfin, on décrit des méthodes diagnostiques qui permettent de déceler la modification du niveau des polypeptides considérés et les mutations dans les séquences nucléotiques qui effectuent le codage desdits polypeptides.
Meissner Paul S.
Ni Jian
Wei Ying-Fei
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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