C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) C12N 5/0789 (2010.01) C12N 15/113 (2010.01) A61K 31/7125 (2006.01) A61K 35/12 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) A61K 48/00 (2006.01) C07K 14/495 (2006.01)
Patent
CA 2412581
The invention relates to TGF-.beta. blocking agent-treated HSC compositions and methods comprising the same. The TGF-.beta. blocking agent-treated stem cells are viable for an extended time in culture without replication or differentiation and upon transfer to appropriate conditions are capable of long term hematopoietic reconstitution.
L'invention concerne des compositions de cellules souches pluripotentielles traitées à l'aide d'un agent de blocage du TGF-.szlig. et les procédés utilisant lesdites compositions. Les cellules souches traitées à l'aide d'un agent de blocage du TGF-.szlig., qui sont viables sur une longue période de temps en culture, sans réplication ni différenciation, sont capables, dès leur transfert dans des conditions appropriées, de reconstitution hématopoïétique à long terme.
Bartelmez Stephen H.
Iversen Patrick L.
Avi Biopharma Inc.
Gowling Lafleur Henderson Llp
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