Transforming growth factor peptides

Details Transforming growth factor peptides Transforming growth factor peptides

C - Chemistry, Metallurgy

07

K

167/37, 530/1.04

C07K 14/495 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/18 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C07K 1/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 16/22 (2006.01) G01N 33/574 (2006.01) G01N 33/58 (2006.01)

Patent

CA 1341535

Novel biological active polypeptides, including a new class of transforming growth factor (TGF) polypeptides which exhibit cell growth promoting properties are dis-closed as well as a process for isolating the TGF poly-peptides from both human and murine cell lines in homo-geneous form. Also disclosed are antigenic oligopeptides derived from the TGF polypeptides and antibodies raised therefrom which have application in the detection and treatment of malignancies and oligopeptides which have the ability to bind with cellular growth factor receptors and thus to interfere with transformation of certain cell lines into a cancerous state. Compositions and methods based on the disclosed peptides for detection and treat-ment of cancer and other proliferative diseases and for cell growth associated treatment, e.g., wound healing and ulcer therapy, are also described.

452799

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