Transforming growth factor peptides

Details Transforming growth factor peptides Transforming growth factor peptides

C - Chemistry, Metallurgy

07

K

167/103, 530/15.

C07K 16/22 (2006.01) A61K 38/18 (2006.01) A61K 38/58 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 1/04 (2006.01) C07K 7/06 (2006.01) C07K 14/495 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) G01N 33/574 (2006.01)

Patent

CA 1341536

Novel biologically active polypeptides, including a new class of transforming growth factor (TGF) polypeptides. which exhibit cell growth promoting properties are disclosed. as well as a process for isolating the TGF polypeptides from both human and murine cell lines in homogeneous form. Also disclosed are antigenic oligopeptides derived from the TGF polypeptides and antibodies raised therefrom which have application in the detection and treatment of malignancies and oligipeptides which have the ability to bind with cellular growth factor receptors and thus to interfere with transformation of certain cell lines into a cancerous state. Compositions and methods based on the disclosed peptides for detection and treatment of cancer and other proliferative diseases and for cell or tissue growth associated treatment, e.g., wound healing. ulcer therapy and bone loss are also described.

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