C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C07K 14/575 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2329939
The invention relates to the finding that animals deficient in the Peg3 gene suffer from a number of phenotypic traits, including obesity, abberant thermoregulation and behavioral defects, including impaired maternal behaviour. The invention provides a transgenic non-human animal which comprises an inactive copy of the Peg3 gene, and the use of such animals as model systems in assays for novel therapies in the treatment of conditions such as those mentioned above.
L'invention concerne la découverte selon laquelle les animaux présentant une carence en gène Peg3 présentent certains phénotypes particuliers, parmi lesquels, l'obésité, une anomalie de la thermorégulation et des défauts du comportement, y compris une altération du comportement maternel. L'invention a pour objet un sujet animal, non humain, transgénique qui comprend une copie inactive du gène Peg3, et l'utilisation de ces animaux comme systèmes modèles dans des dosages pour de nouvelles thérapies dans le traitement des conditions susmentionnées.
Bereskin & Parr
Cambridge University Technical Services Limited
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