Transgenic alzheimer's mouse model vectors and uses thereof

Details Transgenic alzheimer's mouse model vectors and uses thereof Transgenic alzheimer's mouse model vectors and uses thereof

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) A01K 67/00 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C12N 5/00 (2006.01) C12N 15/00 (2006.01) G01N 33/00 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2607852

The present invention provides for a recombinant nucleic acid molecule comprising a humanized mouse /3-amyloid precursor protein ("APP") gene comprising K670N, M671L and V717F mutations and uses thereof. The present invention further provides for a recombinant nucleic acid molecule comprising a region of a calcium-calmodurin dependent kinase Il.alpha. ("CaMKIIa") promoter operatively linked to a /3-amyloid precursor protein ("APP") gene comprising at least one mutation and uses thereof.

L'invention concerne une molécule d'acide nucléique recombinante comprenant un gène de protéine précurseur de 3-amyloïde (APP) / souris humanisée comprenant les mutations K670N, M671L et V717F, et ses utilisations. L'invention concerne également une molécule d'acide nucléique recombinante comprenant une zone de promoteur de kinase II.alpha. calcium/calmodurine dépendante (CaMKIIa) fonctionnellement reliée à un gène de protéine précurseur de 3-amyloïde (APP) comprenant au moins une mutation. L'invention concerne également des utilisations de cette molécule.

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