Transgenic and cloned mammals

Details Transgenic and cloned mammals Transgenic and cloned mammals

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2525148

The invention features methods of making cloned and transgenic mammals, e.g., goats. The methods include making a somatic cell line, e:g., a transgenic somatic cell line which can be used as a donor cell, methods of producing a cloned or transgenic mammal by introducing the genome of a somatic cell into an enucleated oocyte; preferably a naturally matured oocyte which is telophase, to form a reconstructed embryo, and methods of transferring the reconstructed embryo. The invention also includes cell lines, reconstructed embryos and cloned or transgenic mammals.

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