C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A01K 67/027 (2006.01) C07K 14/81 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2350233
The invention features methods of making cloned and transgenic mammals, e.g., goats. The methods include making a somatic cell line, e.g., a transgenic somatic cell line which can be used as a donor cell, methods of producing a cloned or transgenic mammal by introducing the genome of a somatic cell into an enucleated oocyte, preferably a naturally matured oocyte which is telophase, to form a reconstructed embryo, and methods of transferring the reconstructed embryo. The invention also includes cell lines, reconstructed embryos and cloned or transgenic mammals.
L'invention présente des procédés permettant de produire des mammifères (p.ex. chèvres) clonés ou transgéniques. Parmi les procédés figurent la réalisation d'une lignée cellulaire somatique, p.ex. une lignée cellulaire somatique transgénique pouvant être utilisée comme cellule donneuse; des procédés de production d'un mammifère cloné ou transgénique par l'introduction du génome d'une cellule somatique dans un ovocyte énucléé, de préférence ayant atteint maturation de manière naturelle en au stade de télophase, afin de former un embryon reconstitué; ainsi que des procédés de transfert de l'embryon reconstitué. L'invention concerne aussi des lignées cellulaires, des embryons reconstitués et des mammifères clonés ou transgéniques.
Behbodi Esmail
Echelard Yann
Gavin William
Melican David
Ziomek Carol
Genzyme Transgenics Corporation
Mbm Intellectual Property Law Llp
Trustee Of Tufts College
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