C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C07K 16/10 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2474030
A transgenic organism is provided comprising a polynucleotide construct encoding an intracellular antibody which disrupts the catalysis of the production of the xenoantigen galactose .alpha. 1,3 galactose and/or a polynucleotide construct which encodes an intracellular antibody which binds pecifically to a retrovirus protein, such as a PERV particle protein. Also described are mthods for the production of such organisms. Cells, tissues and organs of the transgenic organism may be used in xenotransplantation.
L'invention concerne un organisme transgénique comprenant une construction polynucléotidique codant un anticorps intracellulaire qui fragmente la catalyse de la production du xénoantigène galactose .alpha. 1,3 galactose, et/ou une construction polynucléotidique codant un anticorps intracellulaire qui se lie spécifiquement à une protéine de rétrovirus, telle qu'une protéine particulaire PERV. L'invention concerne également des procédés de production de tels organismes. Des cellules, tissus et organes de cet organisme transgénique peuvent être utilisés dans la xénotransplantation.
Dekker Sylvia
Drabek Dubravka
Grosveld Franklin Gerardus
Erasmus University
Erasmus University Medical Center Rotterdam
Smart & Biggar
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