C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) A61K 49/00 (2006.01) C07K 14/47 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2290039
The present invention relates to a transgenic non-human animal embryo laking native presenilin (1) and a transgenic non-human animal having only a non- native presenilin (1). The transgenic animals and cells derived therefrom can be used in the study of the expression pattern, activity and modulators of presenilin (1), in the study of the role of presenilin (1) in Alzheimer's Disease and in the study of disorders of the central nervous system.
La présente invention concerne un embryon animal transgénique exempt de préséniline 1 native et un animal transgénique ne possédant qu'une préséniline 1 non native. Les animaux et les cellules transgéniques qui en résultent peuvent être utilisés pour l'étude des schémas d'expression, de l'activité et des modulateurs de la préséniline 1, pour l'étude du rôle joué par la préséniline 1 dans la maladie d'Alzheimer et pour l'étude des troubles du système nerveux central.
Jiang Ping
Qian Su
Sisodia Sangram S.
Van Der Ploeg Leonardus H.t.
Wong Philip C.
Johns Hopkins University
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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