Transgenic animal having an amyloid precursor protein with a...

Details Transgenic animal having an amyloid precursor protein with a... Transgenic animal having an amyloid precursor protein with a...

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) A01K 67/00 (2006.01) C12N 15/00 (2006.01) G01N 33/00 (2006.01)

Patent

CA 2525584

The present invention provides transgenic animals having an amyloid precursor protein wherein the amino acids flanking the &bgr; secretase cleavage site are NF and EV. The invention also provides tissues and cell lines derived from such animals. The invention further provides methods of screening candidate compounds to determine whether the compounds can alter the rate of cleavage of amyloid precursor protein by &bgr; secretase.

Cette invention concerne des animaux transgéniques comprenant une protéine précurseur amyloïde, les acides aminés flanquant le site de clivage de la .beta.-sécrétase étant NF et EV. Cette invention concerne également des tissus et des lignées cellulaires dérivés de ces animaux. Cette invention concerne en outre des procédés de criblage de composés candidats permettant de déterminer si les composés peuvent modifier la vitesse de clivage de la protéine précurseur amyloïde par la .beta.-sécrétase.

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