C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2314357
The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regulated manner. The invention also provides methods for producing phenotypic indicators of cartilage-degenerative disease in a mammal and methods for determining the potential of a composition to counteract cartilage-degenerative disease. The invention also provides isolated nucleic acids encoding proMMP polypeptides that exhibit constitutive enzymatic activity and isolated proMMP polypeptides.
L'invention concerne des systèmes modèles animaux de lutte contre une maladie dégénérative du cartilage. Ces systèmes modèles comprennent des animaux transgéniques pouvant exprimer des enzymes recombinantes d'altération matricielle (MDE), en particulier des métalloprotéases matricielles (MMP), par régulation temporelle et spatiale. L'invention concerne également des procédés de production d'indicateurs phénotypiques d'une maladie dégénérative du cartilage chez un mammifère, et des procédés pour déterminer le pouvoir d'une composition de lutter contre une maladie dégénérative du cartilage. L'invention concerne enfin des acides nucléiques isolés codant des polypeptides proMMP présentant une activité enzymatique constitutive et des polypeptides proMMP isolés.
Killar Loran Marie
Neuhold Lisa Ann
American Home Products Corporation
Smart & Biggar
Wyeth
LandOfFree
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