Transgenic animal model for neurodegenerative diseases

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C07K 14/47 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2383564

The present application refers to a mouse parkin2 DNA- and protein sequence, containing mutations or deletions causing Parkinson's disease in a human if occurring in the according human sequence, the construction of a transgenic non-human animal containing such a mutated DNA sequence and therefore expressing no or a less active or non-active parkin protein as well as the use of this transgenic animal as a model for neurodegenerative diseases.

La présente invention concerne une séquence de protéine et d'ADN parkin2 d'une souris, qui contient des mutations ou des délétions provoquant la maladie de Parkinson chez un être humain, si elles se produisent dans une séquence humaine correspondante. Ladite invention concerne également l'élaboration d'un animal non humain transgénique contenant une telle séquence d'ADN mutée et donc n'exprimant aucune protéine parkin ou exprimant cette même protéine en moins active ou en non active, ainsi que l'utilisation de cet animal transgénique en tant que modèle de maladies neurovégétatives.

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