Transgenic animal model for obesity expressing foxc2

Details Transgenic animal model for obesity expressing foxc2 Transgenic animal model for obesity expressing foxc2

A - Human Necessities

01

K

A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/435 (2006.01) C07K 14/575 (2006.01) C12N 5/16 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2400342

According to the invention, a major role for the winged helix protein FOXC2 in regulating energy balance and adiposity is demonstrated. The invention relates to transgenic non-human mammalian animals being capable of expressing the human FOXC2 gene in its adipose tissue. The invention also relates to methods for identifying compounds useful for the treatment of medical conditions related to obesity or diabetes, said compounds being capable of stimulating expression of the human FOXC2 gene, or being capable of stimulating the biological activity of a polypeptide encoded by the human FOXC2 gene. The invention further relates to methods for identifying compounds useful for the treatment of medical conditions related to malnutrition, said compounds being capable of decreasing expression of the human FOXC2 gene, or being capable of decreasing the biological activity of a polypeptide encoded by the human FOXC2 gene.

L'invention démontre le rôle important de la protéine hélice ailée FOXC2 dans la régulation de l'équilibre énergétique et l'adiposité. L'invention concerne des animaux mammifères transgéniques capables d'exprimer le gène FOXC2 humain dans son tissu adipeux. L'invention concerne également des procédés permettant d'identifier des composés utiles dans le traitement d'états pathologiques relatifs à l'obésité ou au diabète, ces composés étant capables de stimuler l'expression du gène FOXC2 humain ou l'activité biologique d'un polypeptide codé par le gène FOXC2 humain. L'invention concerne également des procédés d'identification de composés utiles pour le traitement d'états pathologiques relatifs à la malnutrition, ces composés étant capables de diminuer l'expression du gène FOXC2 humain ou l'activité biologique d'un polypeptide codé par le gène FOXC2 humain.

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