Transgenic animal model of bone mass modulation

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/22 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) C07K 14/51 (2006.01) C12N 5/06 (2006.01) C12N 15/18 (2006.01) C12N 15/85 (2006.01) C12N 15/89 (2006.01) C12Q 1/00 (2006.01) A61K 35/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2446859

The present invention relates to methods and materials used to express the HBM protein in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.

La présente invention concerne des procédés et matières utilisées pour exprimer la protéine HBM de cellules animales et d'animaux transgéniques. La présente invention concerne également des animaux transgéniques exprimant le gène d'une masse osseuse élevée, le gène type sauvage correspondant, et leurs mutants. L'invention fournit des acides nucléiques, y compris des séquences de codage, des amorces et sondes oligonucléotidiques, des protéines, des vecteurs de clonage, des vecteurs d'expression, des hôtes transformés, des procédés de développement de compositions pharmaceutiques, des procédés d'identification de molécules impliquées dans le développement osseux, et des procédés de diagnostic et de traitement de maladies impliquées dans le développement osseux. Dans des modes de réalisation préférés, la présente invention concerne des procédés de traitement, de diagnostic et de prévention de l'ostéoporose.

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