A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 9/88 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2450452
It is intended to provide a novel transgenic animal wherein .gamma.- aminobutyric acid neurons can be visualized in vivo; a method of constructing the same; and a novel model animal of palatoschisis. A transgenic animal wherein a green fluorescent protein gene is inserted into the same reading frame as an exon of a glutamate decarboxylase gene, and a model animal of palatoschisis comprising the above transgenic animal. In the transgenic animal, the fluorescence of the knockin fluorescent gene at the expression site of the glutamate decarboxylase can be observed and thus the expression site of the gene in vivo can be identified. Moreover, it is useable as a model animal of palatoschisis in treating palatoschisis.
L'invention concerne un nouvel animal transgénique dans lequel il est possible de visualiser in vivo des neurones d'acide .gamma.-aminobutyrique. Procédé servant à l'élaborer et nouveau modèle animal de fente palatine. Animal transgénique dans lequel on a inséré un gène de protéine vert fluorescent dans le même cadre de lecture qu'un exon d'un gène de glutamate décarboxylase et modèle animal de fente palatine constitué par cet animal transgénique. On peut observer dans cet animal transgénique, la fluorescence du gène fluorescent introduit au niveau du site d'expression de glutamate décarboxylase et, de ce fait, identifier le site d'expression du gène in vivo. On peut, de plus, utiliser cet animal transgénique en tant que modèle animal de fente palatine afin de traiter cette dernière.
Yanagawa Yuchio
Japan Science And Technology Agency
Ridout & Maybee Llp
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