Transgenic animals comprising a humanized immune system

Details Transgenic animals comprising a humanized immune system Transgenic animals comprising a humanized immune system

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/725 (2006.01) C07K 14/73 (2006.01) C07K 14/74 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2432133

The invention relates to transgenic non-human animals capable of producing heterologous T-cell receptors and transgenic non-human animals having inactivated endogenous T-cell receptor genes. The invention also relates to methods and vectors and transgenes for making such transgenic non-human animals.

L'invention concerne des animaux transgéniques non humains capables de produire des récepteurs de cellules T hétérologues et des animaux transgéniques non humains qui présentent des gènes de récepteurs de cellules T endogènes à l'état inactivé. L'invention concerne également des procédés ainsi que des vecteurs et des transgènes utilisables pour l'élaboration des animaux transgéniques considérés.

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