Transgenic animals containing a dominant negative mutant...

Details Transgenic animals containing a dominant negative mutant... Transgenic animals containing a dominant negative mutant...

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A01K 67/00 (2006.01) C12N 5/06 (2006.01) C12N 9/12 (2006.01) C12N 15/85 (2006.01) G01N 33/50 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2372542

The present invention provides a genetically-modified, non-human mammal having an altered body fat composition, wherein said mammal comprises an exogenous mutant p85 P13-K gene, wherein the expression of said gene is driven by an insulin responsive cell specific promoter. The present invention also relates to transgenic cell lines containing the same mutant gene, as well as methods using both animals and/or cells.

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