A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) C12N 5/078 (2010.01) C07K 16/00 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/13 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2440676
The invention provides compositions and methods for the generation of novel non-human transgenic animals which contain an alteration in a gene of interest. These transgenic animals are capable of generating antibodies, e.g., human monoclonal antibodies, specific for the product of a gene of interest that has been functionally disrupted in the transgenic animal. Furthermore, the methods and compositions of the invention are suitable for use in the treatment, diagnosis, and imaging of disease.
L'invention concerne des compositions et des procédés permettant la création de nouveaux animaux transgéniques autres que l'homme, qui présentent une altération sur un gène donné. Ces animaux transgéniques sont capables de produire des anticorps, p. ex. des anticorps monoclonaux humains, spécifiques du produit d'un gène donné qui a subi une disruption fonctionnelle chez l'animal transgénique. Les procédés et les compositions décrits peuvent en outre être utilisés pour le traitement, le diagnostic et la visualisation de pathologies.
Abbott Gmbh & Co. Kg
Torys Llp
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