Transgenic animals expressing prkag3

Details Transgenic animals expressing prkag3 Transgenic animals expressing prkag3

A - Human Necessities

01

K

A01K 67/027 (2006.01) C12N 9/12 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2474007

Transgenic non-human animals that express the .gamma.3 subunit of PRKAG are described, as well as methods of using the transgenic non-human animals as models for improving treatment, prevention, or diagnosis of diseases related to energy metabolism, including obesity, dyslipidemia, insulin resistance syndrome, and type 2 diabetes.

L'invention concerne des animaux non humains transgéniques qui expriment la sous-unité .gamma.3 de PRKAG, ainsi que des méthodes d'utilisation des animaux non humains transgéniques comme modèles destinés à l'amélioration de traitement, de prévention ou de diagnostic de maladies liées au métabolisme énergétique, notamment l'obésité, la dyslipidémie, le syndrome d'insulino-résistance, et le diabète de type 2.

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