Transgenic animals for assessing drug metabolism and toxicity

Details Transgenic animals for assessing drug metabolism and toxicity Transgenic animals for assessing drug metabolism and toxicity

A - Human Necessities

01

K

A01K 67/027 (2006.01)

Patent

CA 2688438

The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans. One aspect of the invention relates to the use of a human DNA sequence comprising at least part of introns 6 and/or 7 of the human PXR gene.

La présente invention concerne des animaux transgéniques non humains, des tissus ou des cellules dérivés de ces animaux et leurs procédés de production. Les animaux transgéniques non humains ou les tissus ou cellules dérivés de ces animaux fournissent un système capable d'exprimer des protéines humaines responsables du métabolisme d'un médicament à la place de protéines d'animaux non humains endogènes homologues et de l'expression régulée de gènes humains introduits dans l'animal de sorte que l'expression des gènes humains soit régulée d'une manière plus étroitement analogue à celle observée in vivo chez les humains. Un aspect de l'invention concerne l'utilisation d'une séquence d'ADN humaine comprenant au moins une partie des introns 6 et/ou 7 du gène PXR humain.

Affiliated with

Also associated with

Rating

Transgenic animals for assessing drug metabolism and toxicity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transgenic animals for assessing drug metabolism and toxicity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic animals for assessing drug metabolism and toxicity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1506050