Transgenic animals produced by homologous sequence targeting

Details Transgenic animals produced by homologous sequence targeting Transgenic animals produced by homologous sequence targeting

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) A01K 67/027 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 9/10 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2341350

The invention relates to methods and compositions for producing transgenic animals by targeted homologous recombination comprising targeting an exogenous polynucleotide or exogenous complementary polynucleotide pair to a predetermined endogenous DNA target sequence in a target cell by homologous pairing, particularly for altering an endogenous DNA sequence, such as a chromosomal DNA sequence. In certain embodiments, the invention relates to compositions that contain exogenous targeting polynucleotides, complementary pairs of exogenous targeting polynucleotides, chemical substituents of such polynucleotides, and recombinase proteins used in the methods of the invention.

L'invention a trait à des procédés et à des compositions servant à produire des animaux transgéniques par une recombinaison homologue ciblée qui comporte l'étape consistant à cibler un polynucléotide exogène ou une paire de polynucléotides complémentaires exogènes vers une séquence cible d'ADN endogène prédéterminée dans une cellule cible par appariement homologue, en particulier pour modifier une séquence d'ADN endogène telle qu'une séquence d'ADN chromosomique. Dans certains modes de réalisation, l'invention a trait à des compositions qui contiennent des polynucléotides de ciblage exogènes, des paires complémentaires de polynucléotides de ciblage exogènes, des substituants chimiques de ces polynucléotides et des protéines de recombinase utilisées dans les procédés de l'invention.

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