C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) C12N 15/877 (2010.01) A01K 67/02 (2006.01) A01K 67/027 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C12N 15/13 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2689695
The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
La présente invention concerne de nouveaux animaux transgéniques non-humains capables, par stimulation antigénique, de produire des anticorps monovalents se liant à un antigène choisi. L'invention concerne également des transgènes modifiés à chaîne lourde, des procédés de production d'animaux transgéniques non-humains, des procédés d'immunisation d'animaux transgéniques non-humains pour la production d'anticorps monovalents, ainsi que les anticorps pouvant s'obtenir par de tels procédés d'immunisation.
Beurskens Frank
Bleeker Willem Karel
Labrijn Aran Frank
Parren Paul
Schuurman Janine
Borden Ladner Gervais Llp
Genmab A/s
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